Welkin Wellness Private Limited

Anti-dandruff agents are intended to reduce the formation of dandruff flakes. The cause for dandruff is not fully understood but the treatment involves the use of a number of “actives” that function either as antimicrobial agents or as anti-mitotic agents. The choice of “active” depends on the regulatory requirements in the markets that are being served. In the United States, there are five ingredients that are currently approved for use in over the counter (OTC) anti-dandruff products. The two most popular ingredients are zinc pyrithione and selinium sulfide. The other approved “actives” are salicylic acid, sulfur, and coal-tar solution. With the exception of coal tar and salicylic acid, the other three ingredients are used as suspensions in shampoo formulations. In the case of zinc pyrithione, the most popular anti-dandruff active used in the United States, it is supplied as 48% dispersion in water. It is most commonly used at 1.0% active in a shampoo formulation.

When using either selinium sulfide (used at 1.0%) or zinc pyrithione (used at 0.3–2.0%) a suspending agent such as acrylates; C10–30 alkyl acrylates crosspolymer or magnesium aluminum silicate is also needed to keep the “active” uniformly suspended in the shampoo. Since both of these “actives” are insoluble, shampoos that contain them will be opaque. Opacifying agents such as ethylene glycol monostearate (EGMS) or ethylene glycol distearate (EGDS) are frequently used to give the shampoo an attractive opaque/pearlescent appearance instead of a flat “paint” appearance.

• Glucosamine Hydrochloride and Chondroitin Sulphate: These are crucial building blocks for cartilage, helping to repair and maintain its structure.
• Methylsulfonylmethane (MSM): A natural compound known for its anti-inflammatory properties, reducing pain and swelling in the joints.
• Hyaluronic Acid: Helps lubricate joints and improve cartilage function.
• Boswellia serrata and Withania somnifera: Herbal extracts with anti-inflammatory properties.
• Vitamin C and Manganese Sulphate: Essential for collagen production and overall cartilage health. 

• Supports joint flexibility and mobility.
• Aids in cartilage repair and regeneration.
• Reduces inflammation and pain.
• Helps manage conditions like hip dysplasia, osteoarthritis, and other joint disorders.
• Supports joint development in growing pets.
• Assists with recovery after fractures and surgeries. 

Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.1

The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid synovial cells, indicating inhibition of acute (PMN system) and chronic (synovial cell system) inflammatory reactions.

Several studies have reported that carprofen has modulatory effects on both humoral and cellular immune responses. Data also indicate that carprofen inhibits the production of osteoclast-activating factor (OAF), PGE1, and PGE2 by its inhibitory effect in prostaglandin biosynthesis.

Peak blood plasma concentrations are achieved in 1-3 hours after oral administration of 1, 5, and 25 mg/kg to dogs. The mean terminal half-life of carprofen is approximately 8 hours (range 4.5-9.8 hours) after single oral doses varying from 1-35 mg/kg of body weight. After a 100 mg single intravenous bolus dose, the mean elimination half-life was approximately 11.7 hours in the dog. Carprofen is more than 99% bound to plasma protein and exhibits a very small volume of distribution.

Carprofen is eliminated in the dog primarily by biotransformation in the liver followed by rapid excretion of the resulting metabolites (the ester glucuronide of carprofen and the ether glucuronides of 2 phenolic metabolites, 7-hydroxy carprofen and 8-hydroxy carprofen) in the feces (70-80%) and urine (10-20%). Some enterohepatic circulation of the drug is observed

1. Carprofen Caplets is a nonsteroidal anti inflammatory drug NSAID that is used to reduce pain and inflammation soreness due to osteoarthritis and pain following surgery in dogs Carprofen Caplets is a prescription drug for dogs It is available as a caplet and is given to dogs by mouth

• Osteoarthritis: Helps manage pain and inflammation associated with joint wear and tear, especially in aging dogs.
• Post-operative Pain: Effectively controls pain and inflammation following soft tissue and orthopedic surgeries. 

• Carprofen, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting cyclooxygenase (COX) enzymes, primarily COX-2.
• This action reduces the production of prostaglandins, which are chemicals responsible for pain, inflammation, and fever. 

• Administer orally as directed by your veterinarian.
• Typical dosage is 2-4 mg/kg of body weight per day, divided into two doses.
• After seven days, the dose may be reduced to 2 mg/kg per day, given once daily, based on your dog's response and your veterinarian's recommendation.
• Give with food to minimize potential gastrointestinal upset. 

Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.1

The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid synovial cells, indicating inhibition of acute (PMN system) and chronic (synovial cell system) inflammatory reactions.

Several studies have reported that carprofen has modulatory effects on both humoral and cellular immune responses. Data also indicate that carprofen inhibits the production of osteoclast-activating factor (OAF), PGE1, and PGE2 by its inhibitory effect in prostaglandin biosynthesis.

Peak blood plasma concentrations are achieved in 1-3 hours after oral administration of 1, 5, and 25 mg/kg to dogs. The mean terminal half-life of carprofen is approximately 8 hours (range 4.5-9.8 hours) after single oral doses varying from 1-35 mg/kg of body weight. After a 100 mg single intravenous bolus dose, the mean elimination half-life was approximately 11.7 hours in the dog. Carprofen is more than 99% bound to plasma protein and exhibits a very small volume of distribution.

Carprofen is eliminated in the dog primarily by biotransformation in the liver followed by rapid excretion of the resulting metabolites (the ester glucuronide of carprofen and the ether glucuronides of 2 phenolic metabolites, 7-hydroxy carprofen and 8-hydroxy carprofen) in the feces (70-80%) and urine (10-20%). Some enterohepatic circulation of the drug is observed

Rabivax-S Vaccine 1 ml belongs to the category of medicine called immunizing agent used to prevent rabies disease. Rabies is caused by a virus called the rabies virus. It is transmitted to humans and other animals through close contact with saliva from infected animals (bites, scratches, licks on broken skin and mucous membranes). Rabies' symptoms include pain or itching at the site of the bite wound, fever, hydrophobia (fear of water), and intolerance to noise, bright light or air.

Rabivax-S Vaccine 1 ml contains 'Rabies Vaccine, Human' that provides long-lasting protection against infection from the rabies virus. Rabivax-S Vaccine 1 ml helps develop immunity by forming antibodies that protect against infection caused by rabies viruses. It is essential to complete the vaccine course to prevent this fatal disease.

Rabivax-S Vaccine 1 ml will be administered by a healthcare professional. Do not self-administer it. In some cases, you may experience some common side effects like feeling unwell, headache, muscle pain, fever, nausea, injection site swelling, injection site redness, itching, or bruising at the injection site. Most of these side effects of Rabivax-S Vaccine 1 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent and worsen, reach out to your doctor.

If you are allergic to Rabivax-S Vaccine 1 ml or any other vaccination, please tell your doctor. Please inform your doctor if you are using any prescription and non-prescription medications, including vitamins and herbal supplements. Consult your doctor before taking Rabivax-S Vaccine 1 ml if you are pregnant, planning for a pregnancy, or breastfeeding. Rabivax-S Vaccine 1 ml is a cold chain vaccine, and so it has to be stored in the refrigerator between 2-8°C else its efficiency might be lost. Do not freeze.

• Active Ingredients: It combines two potent β-lactam antibiotics: Amoxicillin Sodium (2000 mg) and Cloxacillin Sodium (2000 mg).
• Mechanism of Action:
  • Amoxicillin inhibits the formation of bacterial cell walls, leading to bacterial death.
  • Cloxacillin also works against certain bacteria not affected by amoxicillin, broadening the spectrum of activity. 

• Respiratory tract infections (RTIs)
• Mastitis (clinical and subclinical)
• Fever of bacterial origin
• Deep wound or post-surgical infections
• Septicemia in cattle and buffalo
• Tough infections like metritis, salmonellosis, calf scour, and E. coli infections. 

• Reconstitution: Reconstitute the powder using the provided sterile solvent.
• Administration: Administer intramuscularly or subcutaneously as directed by a veterinarian.
• Preparation: Shake well before use and administer immediately after preparation.
• Discarding: Do not store or use any leftover solution.
• Veterinary Guidance: Always use under the supervision of a licensed veterinarian and follow their prescribed dosage instructions precisely to avoid overdosing. 

• It combines Ceftriaxone, a third-generation cephalosporin antibiotic, with Tazobactam, a beta-lactamase inhibitor.
• Ceftriaxone acts by inhibiting bacterial cell wall synthesis, leading to bacterial death.
• Tazobactam helps Ceftriaxone overcome bacterial resistance by blocking the enzymes (beta-lactamases) that break down antibiotics.## 2. Uses
• Treatment of various bacterial infections, including those affecting the respiratory tract, urinary tract, skin, soft tissues, bones, joints, blood, and brain.
• Management of sepsis and pneumonia.
• Post-surgical infection prevention. 

• Administered by a healthcare professional as an intramuscular (IM) or intravenous (IV) injection/infusion.
• Do not self-administer.
• IV injection should be administered over at least 2–4 minutes.
• IV infusion should be administered over a period of 30 minutes

• Treating ovarian follicular cysts: It helps resolve cysts that interfere with regular ovulation.
• Inducing early postpartum estrus cycles: It stimulates the return to heat after calving.
• Enhancing conception rate after artificial insemination (AI): It promotes ovulation and prepares the uterus for pregnancy.
• Synchronizing estrus: It can be used as part of protocols to synchronize estrus cycles in groups of animals, allowing for fixed-time AI.
• Inducing ovulation in mares: It can be used to induce ovulation and synchronize it more closely with mating. 

• Pregulate contains Buserelin Acetate, a synthetic analog of gonadotropin-releasing hormone (GnRH).
• GnRH stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.
• These hormones play crucial roles in regulating the female reproductive cycle, including follicle development and ovulation.
• By mimicking the action of natural GnRH, Pregulate helps regulate these hormonal releases, leading to improved reproductive outcomes.

• Praziquantel (50 mg): Targets tapeworms by disrupting their metabolism.
• Pyrantel Pamoate (144 mg): Works by paralyzing roundworms and hookworms, aiding in their expulsion.
• Fenbendazole (500 mg): Targets a range of worms including whipworms, roundworms, and some tapeworms by interfering with their energy production. 

• Broad-Spectrum Deworming: Effectively combats various types of intestinal worms, offering comprehensive protection.
• Promotes Health and Well-being: Reduces the risk of malnutrition, anemia, and other health issues caused by parasitic infections.
• Improves Quality of Life: Alleviates symptoms associated with worm infestations, such as diarrhea, vomiting, and weight loss.
• Suitable for all breeds and sizes: When dosed correctly, it is suitable for various dog breeds, including puppies and adult dogs.
• Easy to Administer: The tablets are palatable and can be given directly or mixed with food.
• Vet Recommended: Trusted by veterinarians for its efficacy and safety

Indications: Respiratory and genitourinary tract infections, otitis, cellulitis & secondary bacterial conditions associated with virus disease or post operative infections, swine dysentery, erysipelas and enzootic pneumonia in pigs, foul in the foot, mastitis and calf pneumonia in cattle.

Pack size: 99 ml

Dose: Cattle/Buffaloes IM, SC Injection Each 1 ml for 15-40 kg B.W